Last updated May 30, 2026
Category
Best Oral GLP-1
Pill-form GLP-1 medications — no injections.
- Top pick1
Oral semaglutide for type 2 diabetes
- The only FDA-approved oral GLP-1 receptor agonist, offering needle-free therapy for people who dislike injections
- Strong blood-sugar control: A1C reductions of about 1.0-1.4% at 14 mg, outperforming common oral diabetes drugs like sitagliptin and empagliflozin
- First and only oral GLP-1 with an FDA-approved cardiovascular risk-reduction indication, backed by the 9,650-patient SOUL trial
FDA-approvedBrand-nameDaily oral tabletGLP-1 receptor agonist