Eli Lilly
Pharma maker of Mounjaro and Zepbound (tirzepatide), plus diabetes and other medicines
https://www.lillydirect.comProducts from Eli Lilly
- Top pick1Editor's Choice
FDA-approved tirzepatide for weight loss
- Most effective FDA-approved weight-loss medication to date, with up to about 22.5% average body-weight loss at the 15 mg dose in SURMOUNT-1
- Demonstrated head-to-head superiority over Wegovy (20.2% vs 13.7%) in the SURMOUNT-5 NEJM trial
- Convenient once-weekly injection with a flexible dosing window (can be taken up to 4 days late)
FDA-approvedBrand-nameOnce-weekly injectionDual GIP / GLP-1Insurance eligible - 2Runner-up
Tirzepatide for type 2 diabetes
- Category-leading efficacy: in the SURPASS-2 head-to-head trial it beat injectable semaglutide on both A1C (about 2.3-percentage-point reduction at 15 mg) and weight (roughly 11 kg, about 12%)
- Dual GIP/GLP-1 mechanism delivers strong blood-sugar control plus substantial weight loss as a benefit for people with type 2 diabetes
- Convenient once-weekly injection with a pre-filled pen, no daily pills or daily dosing
Off-label useOnce-weekly injectionDual GIP / GLP-1Insurance eligible - 3Also great
The anytime, no-food-restriction GLP-1 pill
- Only GLP-1 pill that can be taken any time of day with no food or water restrictions
- First-in-class non-peptide small-molecule GLP-1, simplifying manufacturing and dosing
- Phase 3 ATTAIN-1 results published in NEJM with meaningful weight loss and cardiometabolic improvements
FDA-approvedBrand-nameDaily oral tabletInsurance eligible