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HealthVetted

Novo Nordisk

Pharma maker of Ozempic, Wegovy, and Rybelsus (semaglutide), plus diabetes care

https://www.wegovy.com

Products from Novo Nordisk

  1. Top pick
    1

    Wegovy Pill (oral semaglutide 25 mg)

    The first FDA-approved GLP-1 pill for weight loss

    • First and only FDA-approved oral GLP-1 indicated for weight management
    • Phase 3 OASIS 4 weight loss comparable to injectable Wegovy 2.4 mg
    • Also FDA-approved to reduce major adverse cardiovascular events in eligible adults
    FDA-approvedBrand-nameDaily oral tabletGLP-1 receptor agonistInsurance eligible
    8.5/10
    Editorial score
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  2. 2
    Runner-up
    Editor's Choice

    Wegovy

    FDA-approved semaglutide for chronic weight management

    • Among the most effective FDA-approved weight-loss medications, with about 15% average body-weight reduction in large randomized trials (STEP 1 and STEP 5)
    • Documented cardiovascular benefit: a 20% reduction in heart attack, stroke, and cardiovascular death in adults with established heart disease who are overweight or obese (SELECT trial)
    • Once-weekly injection, with a newer once-daily oral pill option approved in December 2025 for patients who prefer to avoid needles
    FDA-approvedBrand-nameOnce-weekly injectionGLP-1 receptor agonistInsurance eligible
    8.3/10
    Editorial score
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  3. 3
    Also great

    Ozempic

    Semaglutide approved for type 2 diabetes

    • Strong, well-documented blood-sugar control, lowering A1C by roughly 1 to 2 percentage points in trials
    • Reduced the combined rate of major cardiovascular events (heart attack, stroke, CV death) by 26% in high-risk patients in the SUSTAIN-6 trial, driven mainly by fewer strokes
    • Newly FDA-approved (January 2025, based on the FLOW trial) to reduce the risk of worsening kidney disease in type 2 diabetes with chronic kidney disease, the broadest indication in its class
    Off-label useOnce-weekly injectionGLP-1 receptor agonistInsurance eligible
    8.2/10
    Editorial score
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  4. 4

    Rybelsus

    Oral semaglutide for type 2 diabetes

    • The only FDA-approved oral GLP-1 receptor agonist, offering needle-free therapy for people who dislike injections
    • Strong blood-sugar control: A1C reductions of about 1.0-1.4% at 14 mg, outperforming common oral diabetes drugs like sitagliptin and empagliflozin
    • First and only oral GLP-1 with an FDA-approved cardiovascular risk-reduction indication, backed by the 9,650-patient SOUL trial
    FDA-approvedBrand-nameDaily oral tabletGLP-1 receptor agonist
    8.0/10
    Editorial score
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  5. 5

    Saxenda

    Daily liraglutide for weight loss

    • Backed by large randomized trials (the SCALE program enrolled thousands of participants) and nearly a decade of real-world safety data since liraglutide's weight-loss approval in 2014
    • Clinically meaningful results: about 63% of patients lost 5% or more of body weight in the pivotal SCALE trial
    • One of the few weight-management drugs FDA-approved for adolescents aged 12-17, not just adults
    FDA-approvedBrand-nameDaily injectionGLP-1 receptor agonist
    7.0/10
    Editorial score
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