DisclosureWe earn commission on partner links; ranking is set by our evidence-based methodology — not advertisers. Read policy

Photo: HealthVetted editorial render
GLP-1 receptor agonist

Photo: HealthVetted editorial render
GLP-1 receptor agonist
| # | Product | Active ingredient | Starting price | FDA status | Score | |
|---|---|---|---|---|---|---|
| 1 | Brightside Health | — | Best ·$95/mo | service | Top ·8.1 | See offer → |
| 2 | BetterHelp | — | $260/mo | service | 7.9 | See offer → |
Brightside is a telehealth platform connecting adults to licensed psychiatric providers and therapists by video and messaging. After a free online assessment, its PrecisionRx clinical-decision-support tool analyzes your symptom pattern against large treatment-outcome datasets to suggest medication options for your prescriber to consider. Care is "measurement-based": you complete standardized PHQ-9 (depression) and GAD-7 (anxiety) questionnaires at intake and at regular intervals, so providers adjust treatment based on tracked scores rather than memory alone. Therapy uses evidence-based approaches such as CBT, supplemented by structured video lessons.
BetterHelp is a digital platform, not a treatment itself. You complete an intake questionnaire, and an algorithm plus human review matches you with a licensed therapist (LCSW, LPC, LMFT, or psychologist), usually within a day or two. You then receive talk therapy through a weekly live session of roughly 30-45 minutes by video, phone, or live chat, plus the ability to message your therapist between sessions. The therapeutic work itself is standard psychotherapy (such as CBT-style approaches), just delivered remotely; you can switch therapists at any time at no extra cost if the fit isn't right.
Brightside has published several peer-reviewed studies, though most are observational and authored by Brightside-affiliated researchers rather than independent randomized trials. A 2022 retrospective analysis in BMC Psychiatry of 6,248 patients who completed at least 12 weeks of medication treatment found about 90% had clinically meaningful improvement on PHQ-9 or GAD-7 and about 75% reached remission (scores below 10); in the larger intent-to-treat sample these figures were lower (roughly 74% improvement and 59% remission), and about 78.9% of patients started treatment within 4 days. A 2022 JMIR Formative Research longitudinal study of 8,581 patients reported the treatment group was about 4.3 times more likely to achieve suicidal-ideation remission (odds ratio 4.31), with a predictive model 77% accurate in classifying complete remission. Because these are single-platform, observational studies, results may not generalize and individual outcomes vary.
A peer-reviewed naturalistic study of 318 BetterHelp users, published in JMIR mHealth and uHealth (2019), found depression symptom severity fell significantly over three months: mean PHQ-9 scores dropped from 12.57 (moderate) to 9.36 (mild), a statistically significant change (p < .001) with a medium effect size (Cohen's d = 0.61). About 37.8% showed clinically significant improvement and 19.8% reached remission. Important limitations: the study had no control group (so it cannot prove BetterHelp caused the improvement), and two of its authors disclosed ties to BetterHelp (a former consultant and a company employee), which is a conflict of interest to keep in mind. Separately, BetterHelp's own 2024 platform-outcomes white paper reports that 72% of clients experienced symptom reduction within 12 weeks, but as company-published, non-peer-reviewed data, that figure should be treated with caution. More broadly, multiple meta-analyses find remote (tele)therapy is generally comparable to in-person care for common conditions like anxiety and depression, though a few studies note a modest in-person advantage for depression.
Brightside itself is a care-delivery service, so "side effects" come from the prescribed medications, typically SSRIs, SNRIs, or bupropion. Common, often temporary effects include nausea, headache, drowsiness or insomnia, dry mouth, dizziness, sexual dysfunction, and appetite or weight changes. Serious but rarer risks include serotonin syndrome, abnormal bleeding, hyponatremia, and worsening mood or new or increased suicidal thoughts, which carry an FDA boxed warning for antidepressants in people under 25, especially early in treatment or after dose changes. Bupropion can lower the seizure threshold. Seek urgent help for suicidal thoughts, severe agitation, or signs of an allergic reaction, and discuss your full medication list and history with your prescriber.
Talk therapy is generally low-risk, but it is not side-effect-free: discussing painful topics can temporarily increase distress, anxiety, or emotional fatigue, and progress can feel slow or stall. Platform-specific drawbacks include inconsistent therapist quality, occasional matching mismatches that require a switch, and limited usefulness in emergencies, since BetterHelp is not a crisis service. The most serious historical concern is privacy: in 2023 the FTC charged BetterHelp with sharing sensitive user data (including health-questionnaire responses, email addresses, and IP data) with advertisers such as Facebook, Snapchat, Criteo, and Pinterest, despite promising to keep that data private. BetterHelp agreed to pay $7.8 million (used for partial consumer refunds) and is now barred from sharing such data for advertising.
As of 2026, self-pay pricing is roughly $95/month for psychiatry (medication management), $299/month for therapy (four video sessions plus unlimited messaging), and about $349/month for combined psychiatry plus therapy. Medications are billed separately: Brightside's mail-order pharmacy is about $15 per fill or your copay if your Rx benefits are accepted, or you can use a local pharmacy or GoodRx. Brightside accepts many major insurers (Aetna, Cigna, Anthem, UnitedHealthcare, and some Medicare/Medicaid plans); with coverage, out-of-pocket can drop to typical copays (often about $15-$30 per session), though actual cost depends on your deductible and plan. Verify your specific coverage before enrolling, since billing surprises are a frequent complaint.
As of 2026, BetterHelp typically costs about $70-$100 per week, which works out to roughly $280-$400 per month; exact pricing varies by location and therapist availability, and the company has been rolling out weekly billing across most of the US. Need-based financial aid can reduce the rate for those who qualify. Historically BetterHelp did not accept insurance, but as of early 2026 it has begun adding coverage through select insurers (such as Cigna, UnitedHealthcare, Aetna, and Optum) in a limited number of states. With strong insurance, traditional in-network therapy (often a $15-$40 copay per visit) can be cheaper; without insurance, BetterHelp's flat rate may undercut typical $100-$200 self-pay session fees.
Brightside is for US adults (and teens 13-17 via a dedicated, therapy-first program available in select states) with depression, anxiety, and related conditions like insomnia, OCD, panic, or PTSD who are comfortable with virtual care. It is a good fit for people wanting medication management, therapy, or both without in-person visits. It is NOT appropriate if you need controlled substances (no Adderall, Xanax, Klonopin, Ativan, or other stimulants/benzodiazepines), have bipolar I or active mania, or are in an acute, life-threatening crisis requiring emergency care. People with complex or treatment-resistant conditions, substance use disorders, or psychosis are generally directed to in-person or higher-level care.
Best for adults with mild-to-moderate anxiety, depression, stress, relationship issues, grief, or life transitions, and for people facing practical barriers to in-person care (rural location, mobility limits, tight schedules). It is NOT appropriate for psychiatric emergencies, active suicidal thoughts, psychosis, severe eating disorders, or substance-use crises. BetterHelp therapists do not prescribe medication, do not provide formal diagnoses for legal or disability purposes, and do not fulfill court-ordered therapy. Anyone in crisis should call or text 988 (Suicide and Crisis Lifeline) or call 911. People who need medication management require a separate prescriber or psychiatry service.
BetterHelp: BetterHelp is a subscription online-therapy platform that pairs you with a licensed therapist for weekly video, phone, or chat sessions plus between-session messaging, costing roughly $280-$400 per month as of 2026. Peer-reviewed data suggest meaningful relief of depression symptoms, but it offers no medication, isn't built for severe illness or crises, and carries a notable privacy history including a 2023 FTC settlement. Both are strong options — match the pick to your specific needs, budget, and clinician's guidance.
Editorial comparison, not medical advice. Discuss options with a qualified clinician. Individual results vary.