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GLP-1 receptor agonist

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GLP-1 receptor agonist
| # | Product | Active ingredient | Starting price | FDA status | Score | |
|---|---|---|---|---|---|---|
| 1 | BetterHelp | — | $260/mo | service | Top ·7.9 | See offer → |
| 2 | Cerebral | — | Best ·$85/mo | service | 6.8 | See offer → |
BetterHelp is a digital platform, not a treatment itself. You complete an intake questionnaire, and an algorithm plus human review matches you with a licensed therapist (LCSW, LPC, LMFT, or psychologist), usually within a day or two. You then receive talk therapy through a weekly live session of roughly 30-45 minutes by video, phone, or live chat, plus the ability to message your therapist between sessions. The therapeutic work itself is standard psychotherapy (such as CBT-style approaches), just delivered remotely; you can switch therapists at any time at no extra cost if the fit isn't right.
Cerebral is not a drug or device; it is a telehealth service that connects you to licensed providers online. After a brief intake assessment, you are matched with a therapist for video or phone sessions using evidence-based methods such as cognitive behavioral therapy (CBT), and/or a prescriber who can evaluate you and prescribe non-controlled psychiatric medications (commonly SSRIs and SNRIs) for conditions like depression and anxiety. The platform handles scheduling, secure messaging, and medication coordination, with prescriptions sent to your pharmacy or shipped. The therapeutic benefit comes from the underlying treatments and the provider relationship, not the app itself.
A peer-reviewed naturalistic study of 318 BetterHelp users, published in JMIR mHealth and uHealth (2019), found depression symptom severity fell significantly over three months: mean PHQ-9 scores dropped from 12.57 (moderate) to 9.36 (mild), a statistically significant change (p < .001) with a medium effect size (Cohen's d = 0.61). About 37.8% showed clinically significant improvement and 19.8% reached remission. Important limitations: the study had no control group (so it cannot prove BetterHelp caused the improvement), and two of its authors disclosed ties to BetterHelp (a former consultant and a company employee), which is a conflict of interest to keep in mind. Separately, BetterHelp's own 2024 platform-outcomes white paper reports that 72% of clients experienced symptom reduction within 12 weeks, but as company-published, non-peer-reviewed data, that figure should be treated with caution. More broadly, multiple meta-analyses find remote (tele)therapy is generally comparable to in-person care for common conditions like anxiety and depression, though a few studies note a modest in-person advantage for depression.
There are no clinical trials of Cerebral the company; the relevant evidence is for the treatments it delivers. A 2022 meta-analysis of randomized controlled trials (Giovanetti et al., Telemedicine and e-Health) found video-based psychotherapy essentially equivalent to in-person therapy for depression (Hedges g of about 0.04, i.e., no meaningful difference), with comparable dropout rates. For medication, Cipriani et al.'s 2018 Lancet network meta-analysis of 21 antidepressants found every drug studied was more effective than placebo for acute major depression, with response odds ratios ranging from about 1.37 to 2.13; the broader literature puts the average antidepressant-versus-placebo effect in the modest range (standardized mean difference roughly 0.30). So the modalities Cerebral uses are well supported, while the size of the benefit is moderate and quality depends heavily on your individual provider.
Talk therapy is generally low-risk, but it is not side-effect-free: discussing painful topics can temporarily increase distress, anxiety, or emotional fatigue, and progress can feel slow or stall. Platform-specific drawbacks include inconsistent therapist quality, occasional matching mismatches that require a switch, and limited usefulness in emergencies, since BetterHelp is not a crisis service. The most serious historical concern is privacy: in 2023 the FTC charged BetterHelp with sharing sensitive user data (including health-questionnaire responses, email addresses, and IP data) with advertisers such as Facebook, Snapchat, Criteo, and Pinterest, despite promising to keep that data private. BetterHelp agreed to pay $7.8 million (used for partial consumer refunds) and is now barred from sharing such data for advertising.
Therapy itself carries little physical risk, though some people feel temporary emotional discomfort discussing difficult topics. The main medical risks come from any prescribed medication. SSRIs and SNRIs commonly cause nausea, headache, insomnia or drowsiness, sexual dysfunction, and weight changes. Serious but less common risks include serotonin syndrome, and antidepressants carry an FDA boxed warning for increased suicidal thoughts and behavior in people under 25, especially early in treatment or after dose changes. Never stop an antidepressant abruptly, as this can cause withdrawal symptoms. Report worsening mood, agitation, or suicidal thoughts to your prescriber immediately, and call or text 988 in a crisis.
As of 2026, BetterHelp typically costs about $70-$100 per week, which works out to roughly $280-$400 per month; exact pricing varies by location and therapist availability, and the company has been rolling out weekly billing across most of the US. Need-based financial aid can reduce the rate for those who qualify. Historically BetterHelp did not accept insurance, but as of early 2026 it has begun adding coverage through select insurers (such as Cigna, UnitedHealthcare, Aetna, and Optum) in a limited number of states. With strong insurance, traditional in-network therapy (often a $15-$40 copay per visit) can be cheaper; without insurance, BetterHelp's flat rate may undercut typical $100-$200 self-pay session fees.
As of 2026, out-of-pocket prices are roughly $175 per therapy session (with discounted bundles such as about $795 for three months of regular sessions), around $60 per month for medication management (billed about $180 per quarter, with the medication itself extra), roughly $365 per month for combined medication plus therapy, and about $325 per month for couples therapy; veterans may receive a discount. With in-network insurance (Cerebral lists partners such as Aetna, Blue Cross Blue Shield, Cigna, Optum, and UnitedHealthcare), copays average around $30 per session. Prices change frequently, so confirm current rates, your coverage, and your exact copay before starting, since some users have reported surprise charges.
Best for adults with mild-to-moderate anxiety, depression, stress, relationship issues, grief, or life transitions, and for people facing practical barriers to in-person care (rural location, mobility limits, tight schedules). It is NOT appropriate for psychiatric emergencies, active suicidal thoughts, psychosis, severe eating disorders, or substance-use crises. BetterHelp therapists do not prescribe medication, do not provide formal diagnoses for legal or disability purposes, and do not fulfill court-ordered therapy. Anyone in crisis should call or text 988 (Suicide and Crisis Lifeline) or call 911. People who need medication management require a separate prescriber or psychiatry service.
Cerebral is designed for US adults 18 and older seeking online therapy or medication management for conditions such as depression, anxiety, insomnia, and bipolar disorder; teen therapy is available in a limited set of states. It is a poor fit for anyone needing controlled substances, including stimulants for ADHD (Adderall, Vyvanse, Ritalin) or benzodiazepines (Xanax), which Cerebral stopped prescribing for most patients in 2022. It is not appropriate for psychiatric emergencies, active suicidal crisis, psychosis, or severe conditions requiring in-person or higher-level care. Anyone in crisis should call or text 988 or go to an emergency room.
Cerebral: Cerebral is a subscription telehealth platform offering online therapy and psychiatric medication management for depression, anxiety, and related conditions across all 50 states. The teletherapy and antidepressants it delivers are evidence-backed treatments. But a history of DOJ and FTC settlements over controlled-substance prescribing, data sharing, and billing means you should watch the subscription terms closely. On balance, BetterHelp edges ahead in our scoring, but the right choice depends on your situation.
Editorial comparison, not medical advice. Discuss options with a qualified clinician. Individual results vary.