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GLP-1 receptor agonist
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GLP-1 receptor agonist
| # | Product | Active ingredient | Starting price | FDA status | Score | |
|---|---|---|---|---|---|---|
| 1 | Brightside Health | — | $95/mo | service | Top ·8.1 | See offer → |
| 2 | Online-Therapy.com | — | Best ·$50/mo | service | 7.6 | See offer → |
Brightside is a telehealth platform connecting adults to licensed psychiatric providers and therapists by video and messaging. After a free online assessment, its PrecisionRx clinical-decision-support tool analyzes your symptom pattern against large treatment-outcome datasets to suggest medication options for your prescriber to consider. Care is "measurement-based": you complete standardized PHQ-9 (depression) and GAD-7 (anxiety) questionnaires at intake and at regular intervals, so providers adjust treatment based on tracked scores rather than memory alone. Therapy uses evidence-based approaches such as CBT, supplemented by structured video lessons.
Online-Therapy.com is a delivery platform built around cognitive behavioral therapy (CBT), one of the most evidence-based talk-therapy models. After you pick your areas of concern and get matched with a licensed therapist, you work through an eight-section online CBT course delivered as video, audio, and text. The program's "toolbox" reinforces the work: interactive worksheets your therapist reviews and responds to (per the company, replies come on weekdays, typically within about 24 hours), a daily journal, an activity-planning tool, progress tests, and yoga/meditation videos. You also get unlimited asynchronous messaging with your therapist, and depending on your plan, one or two 45-minute live sessions per week by video, voice, or text chat. The goal is to help you identify and reframe unhelpful thoughts and behaviors through continuous practice between sessions. The therapy itself is standard CBT, just delivered remotely.
Brightside has published several peer-reviewed studies, though most are observational and authored by Brightside-affiliated researchers rather than independent randomized trials. A 2022 retrospective analysis in BMC Psychiatry of 6,248 patients who completed at least 12 weeks of medication treatment found about 90% had clinically meaningful improvement on PHQ-9 or GAD-7 and about 75% reached remission (scores below 10); in the larger intent-to-treat sample these figures were lower (roughly 74% improvement and 59% remission), and about 78.9% of patients started treatment within 4 days. A 2022 JMIR Formative Research longitudinal study of 8,581 patients reported the treatment group was about 4.3 times more likely to achieve suicidal-ideation remission (odds ratio 4.31), with a predictive model 77% accurate in classifying complete remission. Because these are single-platform, observational studies, results may not generalize and individual outcomes vary.
Online-Therapy.com has not published independent peer-reviewed trials of its own program, so its efficacy case rests on the broad evidence base for guided internet-delivered CBT (iCBT), which closely mirrors its model rather than proving results for this specific platform. A 2020 systematic review and meta-analysis in the Journal of Medical Internet Research found large effects for iCBT in routine care: Hedges' g = 1.18 (95% CI 1.06-1.29) for depression and g = 0.94 (95% CI 0.83-1.06) for anxiety, with outcomes broadly comparable to face-to-face therapy and larger effects on depression when trained professionals provided the guidance (g = 1.27 vs 0.92; this professional advantage was not seen for anxiety). Deterioration rates were low (about 2.5 percent for depression and 3.1 percent for anxiety). These are category-level findings, not measurements of Online-Therapy.com. Reviewer-conducted user surveys (for example, HelpGuide's survey of 100 users) reported roughly 87 percent overall satisfaction, but satisfaction surveys are not clinical outcome measures and should be read as user sentiment, not proof of effectiveness.
Brightside itself is a care-delivery service, so "side effects" come from the prescribed medications, typically SSRIs, SNRIs, or bupropion. Common, often temporary effects include nausea, headache, drowsiness or insomnia, dry mouth, dizziness, sexual dysfunction, and appetite or weight changes. Serious but rarer risks include serotonin syndrome, abnormal bleeding, hyponatremia, and worsening mood or new or increased suicidal thoughts, which carry an FDA boxed warning for antidepressants in people under 25, especially early in treatment or after dose changes. Bupropion can lower the seizure threshold. Seek urgent help for suicidal thoughts, severe agitation, or signs of an allergic reaction, and discuss your full medication list and history with your prescriber.
As talk therapy, Online-Therapy.com has no pharmacological side effects. The most common downside is temporary emotional discomfort when working through difficult thoughts or memories, which is a normal part of CBT. Research on guided iCBT shows low symptom-deterioration rates (roughly 2.5-3 percent), but a minority of people do not improve or feel worse, especially if the modality or therapist fit is poor. Because the platform cannot prescribe medication or provide real-time crisis intervention, the main risk is relying on it for conditions it is not designed to treat. Anyone experiencing worsening symptoms, suicidal thoughts, or a crisis should seek in-person or emergency care immediately and contact 988 or 911.
As of 2026, self-pay pricing is roughly $95/month for psychiatry (medication management), $299/month for therapy (four video sessions plus unlimited messaging), and about $349/month for combined psychiatry plus therapy. Medications are billed separately: Brightside's mail-order pharmacy is about $15 per fill or your copay if your Rx benefits are accepted, or you can use a local pharmacy or GoodRx. Brightside accepts many major insurers (Aetna, Cigna, Anthem, UnitedHealthcare, and some Medicare/Medicaid plans); with coverage, out-of-pocket can drop to typical copays (often about $15-$30 per session), though actual cost depends on your deductible and plan. Verify your specific coverage before enrolling, since billing surprises are a frequent complaint.
As of 2026, Online-Therapy.com is self-pay with three individual tiers billed monthly: Basic about $60/week (roughly $260/month), Standard about $90/week (roughly $390/month), and Premium about $120/week (roughly $520/month); a Couples plan is also offered. New users typically get 20 percent off the first month. It does not accept insurance and is not in-network, but it does accept HSA/FSA cards (your card issuer can still approve or decline the charge), and it provides itemized receipts you can submit to your insurer to seek possible out-of-network reimbursement. Pricing can change with promotions, so confirm current rates at checkout.
Brightside is for US adults (and teens 13-17 via a dedicated, therapy-first program available in select states) with depression, anxiety, and related conditions like insomnia, OCD, panic, or PTSD who are comfortable with virtual care. It is a good fit for people wanting medication management, therapy, or both without in-person visits. It is NOT appropriate if you need controlled substances (no Adderall, Xanax, Klonopin, Ativan, or other stimulants/benzodiazepines), have bipolar I or active mania, or are in an acute, life-threatening crisis requiring emergency care. People with complex or treatment-resistant conditions, substance use disorders, or psychosis are generally directed to in-person or higher-level care.
Best for adults (18+) with mild-to-moderate anxiety, depression, stress, low self-esteem, or relationship issues who are self-motivated and comfortable with a homework-driven CBT format and a digital-first relationship with their therapist. A separate Couples plan exists. It is the wrong choice if you need psychiatric medication (the platform does not prescribe), have a severe or unstable condition, experience active suicidal thoughts, psychosis, mania, or substance-use emergencies, or want to bill in-network insurance. Minors and anyone in crisis should not use it. In an emergency, call 911 or call or text the 988 Suicide and Crisis Lifeline.
Online-Therapy.com: Online-Therapy.com is a legitimate, self-pay platform built around cognitive behavioral therapy (CBT): it pairs you with a state-licensed therapist and a structured digital toolbox (an eight-section CBT course, worksheets, journal, activity plan, tests, and yoga/meditation videos) plus unlimited messaging and, depending on plan, one or two 45-minute live sessions a week. Plans run about $60/$90/$120 per week (billed monthly) as of 2026. It suits motivated adults with mild-to-moderate anxiety, depression, or stress, but it cannot prescribe medication, does not bill insurance, and is not built for crises or severe conditions. On balance, Brightside Health edges ahead in our scoring, but the right choice depends on your situation.
Editorial comparison, not medical advice. Discuss options with a qualified clinician. Individual results vary.