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Photo: HealthVetted editorial render
GLP-1 receptor agonist

Photo: HealthVetted editorial render
GLP-1 receptor agonist
| # | Product | Active ingredient | Starting price | FDA status | Score | |
|---|---|---|---|---|---|---|
| 1 | Legion Pulse Pre-Workout | — | Best ·$45/mo | supplement | Top ·8.1 | See offer → |
| 2 | Crazy Nutrition Intensive Pre-Train | — | Best ·$45/mo | supplement | 6.9 | See offer → |
Legion Pulse combines several ergogenic ingredients at doses studied in research. L-citrulline DL-malate (8g) is converted to arginine and supports nitric oxide production, which can widen blood vessels to improve blood flow and the "pump," and may modestly delay fatigue. CarnoSyn beta-alanine (3.6g per serving) builds muscle carnosine over weeks of consistent use, helping buffer the acid that accumulates during hard sets. Betaine anhydrous (2.5g) may support cellular hydration and power output, though trial results are mixed. Caffeine (350mg) blocks adenosine receptors to reduce perceived effort and boost alertness and performance, while L-theanine (350mg) is added in an attempt to smooth caffeine's jittery edge. Alpha-GPC (300mg) supplies choline and is included primarily to support focus.
Intensive Pre-Train is a multi-ingredient pre-workout you mix with water about 30 minutes before training. Its 200mg of caffeine blocks adenosine receptors to reduce perceived fatigue and sharpen alertness. Citrulline malate (8g, yielding roughly 5.3g L-citrulline) is converted to arginine and then nitric oxide, which can widen blood vessels and support blood flow and the trademark 'pump.' Beta-alanine (3.5g) is a building block of muscle carnosine, an intramuscular acid buffer that, with consistent daily use over several weeks, can help delay fatigue during high-rep sets. Taurine is included for cell hydration and as a general ergogenic, while KSM-66 ashwagandha and EnXtra (Alpinia galanga) extract are added for stress modulation and sustained, lower-jitter focus, and added B-vitamins, vitamin C and other cofactors support energy metabolism. Note that the precise ingredient list (including whether betaine, L-tyrosine or L-arginine are present) has differed across regions and product versions, so check the label on the tub you buy.
The headline ingredients are dosed within researched ranges. A 2021 systematic review and meta-analysis (Vårvik et al., Int J Sport Nutr Exerc Metab) of 8 placebo-controlled trials (137 participants) found acute citrulline malate (6-8g) increased resistance-training repetitions to failure by about 6.4% (p=.022), roughly three extra reps on average, which the authors characterize as a small effect. The ISSN beta-alanine position stand reports that 4-6g daily for at least 2-4 weeks improves high-intensity exercise lasting 1-4 minutes; Pulse's 3.6g per serving accrues benefit with consistent daily use. Betaine has shown modest power and body-composition benefits in some trials but not others. Alpha-GPC at ~600mg increased peak bench-press force and growth-hormone response in a small study (Ziegenfuss et al.), though it did not significantly change peak power; Pulse uses a lower 300mg dose. Caffeine is among the most robustly supported ergogenic aids for power, endurance and reduced perceived exertion. Note that none of these ingredients build muscle directly; the benefit is harder, higher-volume training that can support growth over time.
There are no published clinical trials on Intensive Pre-Train as a finished product, so efficacy rests on its individual ingredients. Caffeine is the most consistently effective pre-workout ingredient: a 2018 Journal of the International Society of Sports Nutrition (JISSN) brief review identifies it as the primary driver of the acute performance benefits of multi-ingredient pre-workouts, and meta-analytic data show a small but reliable effect on muscular endurance (pooled standardized mean difference around 0.30). A 2021 systematic review and meta-analysis in IJSNEM found citrulline malate produced a small benefit on strength-training repetitions to failure (Hedges's g about 0.20, roughly 3 extra reps or a 6.4% increase, p = .02). Beta-alanine has strong ISSN support, but its benefits come from building muscle carnosine over about four weeks at 4-6g/day, so a single 3.5g serving will not act acutely. KSM-66 ashwagandha has numerous randomized trials supporting stress and recovery outcomes, with more mixed evidence for strength. Notably, a 2022 JISSN crossover trial found a caffeinated pre-workout mainly boosted subjective energy and isometric force, with no additional benefit over placebo on leg press or bench press. Overall: meaningful, evidence-backed core doses, but expect a real-but-modest performance edge, not a dramatic one.
The most common effect is harmless tingling or "pins and needles" (paresthesia) from beta-alanine, which the ISSN position stand notes is commonly experienced above 800mg in non-sustained form and generally fades within 60-90 minutes. The 350mg caffeine can cause jitters, racing heart, elevated blood pressure, anxiety, GI upset and insomnia, especially in sensitive users or when stacked with other caffeine sources. The FDA cites 400mg/day as the amount not generally associated with negative effects for healthy adults, so a single full serving leaves little room for additional coffee. Stop use and seek medical care for chest pain, fainting, or irregular heartbeat.
The most common effect is harmless tingling or skin prickling (paresthesia) from 3.5g of beta-alanine, typically starting within minutes and fading within 60-90 minutes. The 200mg of caffeine can cause jitters, rapid heartbeat, elevated blood pressure, anxiety, nausea, headache, GI upset, and insomnia if taken too late; effects are stronger in caffeine-sensitive people or when stacked with coffee or energy drinks. Large doses of citrulline malate or taurine can cause stomach upset in some users. Ashwagandha may cause drowsiness or GI upset and, in rare reports, has been linked to liver injury and thyroid effects. Stop and seek medical care for chest pain, palpitations, fainting, or severe anxiety. Caffeine-related serious events are dose-dependent, so do not exceed one serving, and talk to your doctor if you are unsure whether this product is safe for you.
As of 2026, Legion Pulse runs about $45-46 per tub directly from Legion (around $45.99), which works out to roughly $2.19 per two-scoop serving across about 20-21 servings; a subscription cuts roughly 20% to around $36 per tub (about $35.99, or roughly $1.71 per serving). That's pricier per serving and offers fewer servings than many drugstore pre-workouts. Dietary supplements are paid out of pocket and are generally not covered by insurance, and they are typically not HSA/FSA eligible without a documented medical need. Legion offers a money-back guarantee, and buying multi-tub bundles or subscribing lowers the effective cost; the caffeine-free (stim-free) version is similarly priced (around $44.99 for about 20 servings).
As of 2026, expect roughly $40 for a one-time single tub (commonly 20-30 servings depending on the version), with a Subscribe and Save option cutting about 20-30% off, often landing near $1.50-$2.20 per serving, which places it at or slightly above the typical pre-workout price. Multi-tub bundles lower the per-tub cost. Like all dietary supplements, it is not covered by health insurance, HSA/FSA eligibility is generally not available, and there is no pharmacy or GoodRx-style discount. The main risk-reducer is the brand's 60-day money-back guarantee, which effectively lets you trial it; verify current pricing, serving count, and return-shipping terms before buying, as these change over time.
Best for healthy adult lifters and athletes who are accustomed to caffeine and want clinically dosed, transparently labeled ingredients for resistance training and high-intensity work. Avoid the caffeinated version if you are pregnant or breastfeeding, under 18, caffeine-sensitive, or have heart arrhythmia, uncontrolled high blood pressure, anxiety disorders, or take stimulant or MAOI medications. The 350mg caffeine dose is high, so anyone with a cardiovascular condition should consult a physician first; the stim-free version is a safer choice for evening training or sensitive users. This is general information, not medical advice.
Best for healthy adults who lift or do high-intensity training, tolerate caffeine well, and want a stimulant-based energy-and-pump product. It is NOT for people who are caffeine-sensitive, pregnant or breastfeeding, under 18, or who have heart conditions, high blood pressure, arrhythmia, anxiety disorders, or kidney/liver disease. Anyone on stimulants, MAO inhibitors, blood-pressure or thyroid medication, or with thyroid/autoimmune conditions (relevant to ashwagandha) should consult a physician first. Competitive or drug-tested athletes should be cautious: the brand does not publish independent third-party or banned-substance (e.g., NSF Certified for Sport, Informed Sport) testing. Avoid other caffeine sources the same day, and do not take it late in the day due to sleep disruption. This is a dietary supplement, not a treatment for any medical condition.
Crazy Nutrition Intensive Pre-Train: Crazy Nutrition Intensive Pre-Train is a caffeinated multi-ingredient pre-workout (200mg caffeine, 8g citrulline malate, 3.5g beta-alanine, 2g taurine, plus KSM-66 ashwagandha and EnXtra) with mostly well-dosed, evidence-backed ergogenics. It can support energy, pumps, and high-rep endurance, but it lacks creatine, the exact formula has varied by region and version, and the brand does not publish independent third-party purity or banned-substance testing. It also costs at or above the per-serving average. On balance, Legion Pulse Pre-Workout edges ahead in our scoring, but the right choice depends on your situation.
Editorial comparison, not medical advice. Discuss options with a qualified clinician. Individual results vary.