Curology Custom FormulavsSkinMedica TNS Advanced+ Serum

Curology Custom Formula is a single nightly cream compounded with up to three prescription and cosmeceutical actives selected by a licensed dermatology provider after reviewing your online quiz and uploaded photos. The active most often included is tretinoin, a vitamin A retinoid that binds nuclear retinoic acid receptors to speed skin-cell turnover, help unclog pores, and over time support collagen production while reducing the matrix metalloproteinase enzymes that break down skin structure. Supporting actives may include azelaic acid (antibacterial, anti-inflammatory, brightening), niacinamide (barrier support, oil control, tone evening), clindamycin (a topical antibiotic for inflammatory acne), and depending on your concerns, tranexamic acid, metronidazole, zinc pyrithione, ivermectin, or spironolactone. Together they target acne, post-acne marks, texture, and early signs of aging. Note that Curology's specific multi-ingredient blends have not been studied as a single branded product; the evidence below is for the individual actives.

The serum centers on TNS, a tissue nutrient solution containing human fibroblast-derived growth factors and cytokines that act as signaling molecules to encourage skin cells to maintain collagen and elastin. SkinMedica pairs this with RSC Advanced, a complex of peptides, marine and green-algae extracts, and antioxidants. A two-chamber pump keeps the growth-factor blend separate from the peptide-botanical phase until dispensing to preserve stability.

The individual actives have strong peer-reviewed support, though Curology's specific multi-ingredient blends aren't tested as a branded product. In a 2025 Journal of Clinical Medicine review, tretinoin 0.05% lotion achieved treatment success (clear/almost clear plus a 2-grade improvement) in roughly 25-39% of acne patients at 12 weeks versus about 12-15% for vehicle, and a tretinoin-clindamycin combination reached about 46% success versus 31-33% for either alone. Tretinoin also consistently improves fine wrinkles, mottled pigmentation, and texture in randomized photoaging trials. For niacinamide, a 12-week double-blind study of a 5% topical formulation significantly improved fine lines, hyperpigmentation, and skin texture versus control, and a randomized trial of 4% nicotinamide performed similarly overall to 1% clindamycin for inflammatory acne (with results varying by skin type). A 2023 systematic review found azelaic acid significantly cut inflammatory lesions and erythema in acne and rosacea versus vehicle, though no eligible trials evaluated it for skin aging. Real-world results typically take 8-12 weeks of consistent use.

Manufacturer studies report visible wrinkle and texture improvement starting around two weeks and continuing through 24 weeks, and growth-factor serums do show measurable cosmetic benefit in some independent work. However, the overall evidence base for topical growth factors is far thinner and lower-quality than the decades of randomized trials behind retinoids, so expect modest rather than dramatic results. Individual results vary.

The most common effects are mild and temporary: redness, dryness, flaking, peeling, stinging, and increased sun sensitivity, driven mainly by the tretinoin component. Many users also experience an initial "purge" where breakouts briefly worsen in the first few weeks as cell turnover accelerates; this usually settles. Per FDA tretinoin labeling, local reactions such as erythema (around 5%) and skin irritation/dermatitis (around 4%) are common and generally mild-to-moderate, peaking in the first two to three weeks and reversible on stopping. Serious reactions are uncommon with topical use, since systemic absorption of tretinoin is only about 1-2%. The most important safety issue is pregnancy: topical retinoids like tretinoin are not recommended, and spironolactone (a possible add-in) is contraindicated in pregnancy because of a risk of feminizing a male fetus. Start slowly, moisturize, use daily SPF, and contact a clinician for severe, blistering, or persistent reactions.

As a gentle OTC cosmetic it is well tolerated by most users; occasional mild irritation, redness, or breakouts can occur, and allergic reactions to any component are possible. Patch testing is reasonable for sensitive skin. It does not increase sun sensitivity the way retinoids do, but daily SPF still maximizes anti-aging results.

As of 2026, Curology typically offers a free first month where you pay only shipping (about $5.45). After that, subscriptions generally run about $20 per month for a one-month supply (plus shipping) or roughly $40 every two months with free shipping, with bundled cleanser/moisturizer sets around $60. Independent testing by Innerbody reported a $35 one-time month and a $60 two-month subscription, so expect roughly $20-$40/month for the formula alone, depending on supply size and current promotions. Curology is a cash-pay service that is generally not billed directly to insurance; Curology states the Custom Formula may be HSA/FSA eligible depending on your plan, so check with your administrator. You can change ingredients or cancel anytime through the app, but recurring shipments can add up if you forget to pause.

As of 2026, retail is $295 for a 1 oz / 28.4g bottle, with the lowest realistic price around $236 via the brand's auto-replenishment subscription (up to 20% off). It is HSA/FSA eligible. On a per-ounce basis this is one of the most expensive serums available, which is the main knock against it.

Best for people 13 and older with mild-to-moderate acne, clogged pores, uneven tone, post-acne dark spots, or early fine lines who want prescription-strength results without an in-person visit (those aged 13-17 need parental or guardian consent). It also suits busy people who prefer async, app-based care. Avoid it if you are pregnant, trying to conceive, or breastfeeding, because tretinoin (and spironolactone, if prescribed) are not recommended in pregnancy. People with severe cystic or nodular acne, active rosacea flares, or complex medical skin disease are usually better served by an in-person dermatologist who can examine the skin directly and consider oral medications. Always disclose other medications, allergies, and health conditions during your consult, and treat your provider's guidance, not this article, as the final word.

Adults seeking anti-aging benefits without a prescription, including those who cannot tolerate retinoids. As an OTC cosmetic there is no medical gatekeeping, though pregnant or breastfeeding users and anyone with sensitivities should review ingredients with a clinician.