Elysium BasisvsTimeline Mitopure (Urolithin A)

Each two-capsule serving delivers 250 mg of nicotinamide riboside, a vitamin B3 form the body converts into NAD+, a coenzyme essential to mitochondrial energy production and DNA repair that naturally declines with age. The 50 mg of pterostilbene is included as a polyphenol intended to support sirtuin signaling pathways tied to cellular stress response.

Urolithin A is a metabolite your gut bacteria make from ellagitannins in pomegranate and berries, though many people produce little of it. Each 500 mg daily dose of Mitopure delivers a standardized, bioavailable form that triggers mitophagy, the cellular process of recycling damaged mitochondria, which helps muscle cells preserve mitochondrial quality and energy output as they age.

In an 8-week randomized, double-blind, placebo-controlled trial of 120 healthy adults aged 60-80 published in npj Aging and Mechanisms of Disease, the recommended dose raised whole-blood NAD+ by roughly 40% versus placebo (and ~90% at double dose), sustained over the study period with no serious adverse events. The evidence establishes that Basis reliably increases NAD+; it does not yet demonstrate clinical longevity or disease outcomes.

Randomized, double-blind, placebo-controlled trials published in Cell Reports Medicine (2022, middle-aged adults) and JAMA Network Open (2022, older adults) found that 500 mg/day Urolithin A improved muscle strength (around 12% in one trial), exercise endurance, and biomarkers of mitochondrial health versus placebo. The evidence is strongest for muscle and mitochondrial function; it does not demonstrate extended lifespan in humans.

Generally well tolerated; the published trial reported no serious adverse events. Mild, infrequent effects can include nausea, headache, or warmth/flushing typical of the niacin family. Stop and consult a clinician if you notice an unexpected reaction.

Across 25+ human studies Mitopure has shown a strong safety profile and holds FDA GRAS status. Infrequent effects can include mild digestive discomfort or nausea. Stop and consult a clinician if you experience an unexpected reaction.

As of 2026, $50/month on subscription or $65 for a one-time 30-day pouch directly from Elysium; prepaid annual plans reduce the per-month cost. Not covered by insurance.

As of 2026, roughly $85-$95/month on longer subscriptions, $112.50/month on a basic monthly plan, or $125 for a one-time 30-day softgel bottle from Timeline. Powder and gummy formats are also sold. Not covered by insurance.

Marketed to healthy adults seeking cellular-aging support. Not intended for anyone who is pregnant or breastfeeding, and people with liver conditions or on prescription medications should consult a clinician first. This is educational information, not medical advice.

Marketed to healthy adults, particularly those focused on muscle and mitochondrial health with age. Not intended for those pregnant or breastfeeding; consult a clinician if you have a medical condition or take medications. This is educational information, not medical advice.