DisclosureWe earn commission on partner links; ranking is set by our evidence-based methodology — not advertisers. Read policy

Photo: HealthVetted editorial render
GLP-1 receptor agonist

Photo: HealthVetted editorial render
GLP-1 receptor agonist
| # | Product | Active ingredient | Starting price | FDA status | Score | |
|---|---|---|---|---|---|---|
| 1 | Hims Erectile Dysfunction Treatment | — | Best ·$1/mo | approved | Top ·8.3 | See offer → |
| 2 | Wisp OMG! Cream (Sildenafil Cream) | — | $11/mo | compounded | 7.4 | See offer → |
Sildenafil and tadalafil are PDE5 inhibitors. They prevent the breakdown of cyclic GMP in penile tissue, so when you are sexually aroused, smooth muscle relaxes, arteries dilate, and blood fills the erectile chambers. They do not create desire or work without stimulation; they amplify the body's normal erection pathway.
OMG! Cream delivers sildenafil, a PDE5 inhibitor, directly to clitoral tissue. The intent is to locally relax smooth muscle and increase blood flow, supporting engorgement, lubrication, and heightened sensitivity within minutes of application, while minimizing the systemic exposure you would get from a pill.
PDE5 inhibitors are the most rigorously studied oral ED therapy, with randomized trials showing the majority of men achieve improved erections versus placebo. Hims dispenses the same generic molecules used at retail pharmacies; the difference is delivery and price, not the underlying evidence. The compounded chewable mints rely on those same actives but have not been studied or approved as finished products.
Sildenafil's vasodilatory mechanism is well established, and a topical application aims to harness that locally for arousal. However, evidence specifically supporting topical sildenafil for female sexual arousal disorder is limited and mixed, far less robust than the data for oral PDE5 inhibitors in men. Many users report subjective improvement in sensation, but this is a lightly studied, compounded use.
Most side effects are mild and dose-related: headache, flushing, congestion, and indigestion. Seek emergency care for an erection lasting more than four hours or sudden vision or hearing loss. Never combine with nitrates. This is educational information, not medical advice; individual results vary.
Because it is applied topically, systemic side effects are uncommon; the most likely issues are local irritation, tingling, warmth, or redness. The arginine-free formula is designed to avoid triggering herpes outbreaks. Stop use and consult a provider if irritation persists. This is educational information, not medical advice; individual results vary.
Headline pricing such as 'tadalafil from $1/dose' generally assumes a larger quarterly commitment; first-month or smaller orders cost more per dose. There is no insurance billing, but the cash prices on generics are typically lower than brand-name copays. Expect optional add-ons that can raise your total.
Subscriptions start around $11/month for a single bottle on a multi-month plan and roughly $20/month for two; one-time bottles are about $39 (one) or $66 (two). The consultation and prescription are folded into the cash price, and nothing is billed to insurance. Promotional first-order discounts are common.
Adults assigned male at birth seeking ED treatment, who complete an online medical questionnaire and are cleared by a licensed provider. Not appropriate for men taking nitrates or certain blood-pressure drugs, or with specific cardiovascular conditions; a clinician makes the final call.
Adults assigned female at birth seeking help with physical arousal, lubrication, or sensation, who complete Wisp's online intake and are cleared by a licensed provider. A clinician screens for contraindications; it is not intended to diagnose or treat low desire on its own.
Wisp OMG! Cream (Sildenafil Cream): Wisp's OMG! Cream is an affordable, low-risk way to try topical sildenafil for arousal and orgasm, but it is compounded and the evidence base for women is thin, so set realistic expectations. On balance, Hims Erectile Dysfunction Treatment edges ahead in our scoring, but the right choice depends on your situation.
Editorial comparison, not medical advice. Discuss options with a qualified clinician. Individual results vary.