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Photo: HealthVetted editorial render
GLP-1 receptor agonist

Photo: HealthVetted editorial render
GLP-1 receptor agonist
| # | Product | Active ingredient | Starting price | FDA status | Score | |
|---|---|---|---|---|---|---|
| 1 | Legion Pulse Pre-Workout | — | Best ·$45/mo | supplement | Top ·8.1 | See offer → |
| 2 | Momentous Creatine Monohydrate | — | $50/mo | supplement | 8.0 | See offer → |
Legion Pulse combines several ergogenic ingredients at doses studied in research. L-citrulline DL-malate (8g) is converted to arginine and supports nitric oxide production, which can widen blood vessels to improve blood flow and the "pump," and may modestly delay fatigue. CarnoSyn beta-alanine (3.6g per serving) builds muscle carnosine over weeks of consistent use, helping buffer the acid that accumulates during hard sets. Betaine anhydrous (2.5g) may support cellular hydration and power output, though trial results are mixed. Caffeine (350mg) blocks adenosine receptors to reduce perceived effort and boost alertness and performance, while L-theanine (350mg) is added in an attempt to smooth caffeine's jittery edge. Alpha-GPC (300mg) supplies choline and is included primarily to support focus.
Creatine is a compound your body makes from amino acids and stores mostly in muscle as phosphocreatine. During short, intense effort such as lifting or sprinting, phosphocreatine helps rapidly regenerate ATP, your cells' immediate energy currency, which can let you sustain a few extra reps or seconds of maximal work. Daily supplementation raises muscle creatine stores above what diet alone typically provides, supporting greater training volume and, combined with resistance training, gains in strength and lean mass over time. It also draws water into muscle cells. Momentous supplies this as creatine monohydrate (Creapure), the most-studied and most clinically effective form of creatine.
The headline ingredients are dosed within researched ranges. A 2021 systematic review and meta-analysis (Vårvik et al., Int J Sport Nutr Exerc Metab) of 8 placebo-controlled trials (137 participants) found acute citrulline malate (6-8g) increased resistance-training repetitions to failure by about 6.4% (p=.022), roughly three extra reps on average, which the authors characterize as a small effect. The ISSN beta-alanine position stand reports that 4-6g daily for at least 2-4 weeks improves high-intensity exercise lasting 1-4 minutes; Pulse's 3.6g per serving accrues benefit with consistent daily use. Betaine has shown modest power and body-composition benefits in some trials but not others. Alpha-GPC at ~600mg increased peak bench-press force and growth-hormone response in a small study (Ziegenfuss et al.), though it did not significantly change peak power; Pulse uses a lower 300mg dose. Caffeine is among the most robustly supported ergogenic aids for power, endurance and reduced perceived exertion. Note that none of these ingredients build muscle directly; the benefit is harder, higher-volume training that can support growth over time.
Creatine monohydrate, the exact compound in Momentous, is the form the International Society of Sports Nutrition (ISSN) calls "the most effective ergogenic nutritional supplement currently available" for increasing high-intensity exercise capacity and lean body mass during training. A 2025 systematic review and meta-analysis of 20 randomized controlled trials (1,093 adults aged 55+) found that combining creatine with exercise significantly improved one-rep-max strength versus exercise alone (mean difference 2.12 kg, P=0.001). The same analysis found a modest reduction in body-fat percentage (mean difference -0.55%, P=0.026), though the authors caution this body-composition finding was fragile and lost statistical significance when one influential study was removed. Benefits accrue with consistent daily use combined with training, not from the powder alone. Momentous's specific advantage is verified purity: third-party testing reported by the brand shows 99.8% potency accuracy with no detectable heavy metals, and a certificate of analysis is published per batch.
The most common effect is harmless tingling or "pins and needles" (paresthesia) from beta-alanine, which the ISSN position stand notes is commonly experienced above 800mg in non-sustained form and generally fades within 60-90 minutes. The 350mg caffeine can cause jitters, racing heart, elevated blood pressure, anxiety, GI upset and insomnia, especially in sensitive users or when stacked with other caffeine sources. The FDA cites 400mg/day as the amount not generally associated with negative effects for healthy adults, so a single full serving leaves little room for additional coffee. Stop use and seek medical care for chest pain, fainting, or irregular heartbeat.
Creatine is among the most extensively studied supplements and has a strong safety record in healthy people. The most common effect is a small increase in body weight, often around 2-4 lb early on, which is largely water drawn into muscle cells (intracellular), not fat, and is reversible if you stop. Some users, especially during a high-dose loading phase, report mild gastrointestinal upset, bloating, or stomach discomfort; these are reduced by skipping loading and taking a steady 5g maintenance dose with water. Serious adverse effects are rare in healthy individuals. Despite persistent myths, the ISSN concluded there is no compelling evidence that short- or long-term use (up to 30 g/day for 5 years) harms kidney function in otherwise healthy people. Anyone with existing kidney disease, another medical condition, or who takes medications affecting the kidneys should consult a doctor first.
As of 2026, Legion Pulse runs about $45-46 per tub directly from Legion (around $45.99), which works out to roughly $2.19 per two-scoop serving across about 20-21 servings; a subscription cuts roughly 20% to around $36 per tub (about $35.99, or roughly $1.71 per serving). That's pricier per serving and offers fewer servings than many drugstore pre-workouts. Dietary supplements are paid out of pocket and are generally not covered by insurance, and they are typically not HSA/FSA eligible without a documented medical need. Legion offers a money-back guarantee, and buying multi-tub bundles or subscribing lowers the effective cost; the caffeine-free (stim-free) version is similarly priced (around $44.99 for about 20 servings).
As of 2026, Momentous Creatine Monohydrate runs about $39.95 for a 90-serving (5g) tub direct from livemomentous.com, roughly $0.44 per serving, dropping to about $29.96 (around $0.33/serving) with the 25%-off Subscribe & Save option. Single-serve travel packets and chewable versions cost more per gram. This is a premium price: commodity creatine monohydrate tubs often cost around $0.10-$0.20 per serving, and some other NSF-tested brands undercut Momentous. Creatine is a general supplement, so it is typically not covered by health insurance, and HSA/FSA eligibility varies by plan and retailer, so confirm before assuming reimbursement. The value here is the NSF Certified for Sport testing and Creapure sourcing, not a superior or stronger active dose.
Best for healthy adult lifters and athletes who are accustomed to caffeine and want clinically dosed, transparently labeled ingredients for resistance training and high-intensity work. Avoid the caffeinated version if you are pregnant or breastfeeding, under 18, caffeine-sensitive, or have heart arrhythmia, uncontrolled high blood pressure, anxiety disorders, or take stimulant or MAOI medications. The 350mg caffeine dose is high, so anyone with a cardiovascular condition should consult a physician first; the stim-free version is a safer choice for evening training or sensitive users. This is general information, not medical advice.
Best for healthy adults doing resistance or high-intensity training who want strength, power, and lean-mass support, and especially drug-tested athletes who need NSF Certified for Sport assurance. Vegetarians and vegans may respond more strongly because dietary creatine comes mainly from meat and fish, leaving their baseline muscle stores lower. Older adults using it alongside exercise may see improvements in strength and body composition. Avoid or consult a clinician first if you have kidney, liver, or heart disease, uncontrolled high blood pressure, are pregnant or breastfeeding, or are under 18, as data in these groups is more limited. Anyone on medications that affect kidney function should check with a doctor before starting.
Momentous Creatine Monohydrate: Momentous Creatine Monohydrate is a premium, single-ingredient Creapure creatine powder that is NSF Certified for Sport and third-party tested for purity. At 5g per serving and roughly $30-$40 for 90 servings, it pairs gold-standard, well-researched creatine monohydrate with elite contamination testing. The creatine itself is the same active compound found in far cheaper tubs, so it is worth the premium mainly if batch-level certification and verified purity matter to you. Both are strong options — match the pick to your specific needs, budget, and clinician's guidance.
Editorial comparison, not medical advice. Discuss options with a qualified clinician. Individual results vary.