Transparent Labs VitalityvsMaximus Enclomiphene Protocol

Vitality does not contain testosterone; instead it stacks plant extracts and minerals thought to support the body's own production. KSM-66 ashwagandha is an adaptogen that may lower cortisol and stress signaling, which can indirectly favor testosterone. Tongkat ali (Eurycoma longifolia, LJ100) is theorized to free up bound testosterone and support luteinizing hormone. PrimaVie shilajit and its fulvic acid have been associated with higher total and free testosterone in one trial. Zinc and boron are cofactors involved in testosterone metabolism, while DIM and quercetin are included to support estrogen metabolism, and BioPerine (black pepper extract) is added to improve absorption of the other ingredients. Note these are proposed mechanisms from individual-ingredient research, not effects demonstrated for the combined product.

Enclomiphene is the trans-isomer of clomiphene. It occupies estrogen receptors in the hypothalamus so the brain 'thinks' estrogen is low, which ramps up GnRH and downstream pituitary LH and FSH. That hormonal push tells the testes to make more testosterone naturally — which is why, unlike injected testosterone, it tends to maintain (rather than suppress) sperm production.

Evidence is for the individual ingredients at these doses, not the finished blend (no published trial tests Vitality itself). In Pandit et al. 2016 (Andrologia), 250 mg of PrimaVie shilajit twice daily for 90 days raised total testosterone about 20%, free testosterone about 19%, and DHEA-S about 31% versus placebo in healthy men aged 45-55. A 2022 systematic review and meta-analysis in Medicina (Leisegang et al.) found Eurycoma longifolia significantly increased serum total testosterone across randomized trials (a large but statistically heterogeneous pooled effect), with benefits noted in both healthy and hypogonadal men. An ashwagandha trial in aging, overweight men aged 40-70 (Lopresti et al. 2019, American Journal of Men's Health, using a 21 mg/day withanolide-glycoside extract) found a 14.7% greater rise in salivary testosterone and an 18% greater rise in DHEA-S versus placebo, though it found no significant improvement in fatigue, vigor, or sexual well-being. Real-world results are modest and highly individual; some users report energy or libido benefits, others little change.

Randomized Phase II trials found enclomiphene restored morning total testosterone to levels comparable to topical testosterone gel in men with secondary hypogonadism, while raising LH/FSH and preserving sperm counts. A 2025 systematic review and meta-analysis of SERM therapy reported a mean total-testosterone increase of roughly 274 ng/dL versus placebo. Evidence is solid for short-to-medium-term T restoration; long-term outcome data remain limited.

Most users tolerate Vitality well at the recommended dose. Common, usually mild effects can include digestive upset, drowsiness or sedation from ashwagandha, headache, and occasional GI discomfort from zinc or DIM (DIM can also harmlessly tint urine). More serious but rare concerns center on ashwagandha and tongkat ali: the NIH LiverTox database rates ashwagandha a probable cause of clinically apparent liver injury, with documented case reports of jaundice and cholestatic hepatitis (rare cases have required hospitalization or transplant), and ashwagandha may alter thyroid hormone levels (Denmark banned it in food supplements in 2020 over thyroid, sex-hormone, and reproductive concerns, though industry groups dispute that assessment). Tongkat ali has been associated with raised liver enzymes in some reports. Stop use and see a doctor if you develop jaundice, dark urine, abdominal pain, unusual fatigue, or a rapid heartbeat. As a dietary supplement, Vitality is not reviewed by the FDA for safety and efficacy the way prescription drugs are.

In clinical studies side effects were generally infrequent and mild — headache, nausea, hot flashes, dizziness, or GI upset. Rarer concerns include mood changes and visual disturbances (a known SERM class effect); any vision change warrants stopping and contacting your clinician. This is educational information, not medical advice.

As of 2026, a 60-capsule bottle (30 servings, roughly a one-month supply) runs about $46-$55 depending on retailer (about $46-$47 direct from Transparent Labs, around $54.99 at Amazon and Vitamin Shoppe), or roughly $1.55-$1.85 per serving. Subscribe and save typically takes about $6 off plus free shipping, dropping the direct price to around $41. As a dietary supplement it is not covered by insurance; FSA/HSA cards may apply at some retailers. Buying the generic single ingredients separately is cheaper but sacrifices the matched dosing and third-party testing. Prices vary by retailer and promotion, so confirm the current price at checkout.

As of 2026, the enclomiphene-only plan is advertised from $99.99/month on a committed annual plan and $199.99/month month-to-month. Required testosterone lab panels in the first two months run $99.99 each and are billed separately, so realistically budget for medication plus labs in your early months. Compounded medication is generally not insurance-reimbursable.

Best suited for healthy adult men (often 30+) noticing fatigue, low drive, high stress, or sluggish recovery who want natural hormone support alongside diet, sleep, and resistance training. It is NOT for women, anyone under 18, or men seeking treatment for diagnosed hypogonadism (that requires a physician). Avoid or consult a doctor first if you have liver disease, thyroid disorders, are on thyroid, blood-pressure, sedative, or blood-sugar medication, have a hormone-sensitive condition, or are pregnant or breastfeeding. Ashwagandha has documented case reports of liver injury and may affect thyroid hormone levels, and tongkat ali has been linked to raised liver enzymes in some reports. As with any supplement, discuss it with your clinician before starting, especially if you take prescription drugs.

Adult men with lab-documented low testosterone and intact testicular function (secondary hypogonadism). You must complete bloodwork and a clinician review; men seeking fertility preservation are common candidates. Not appropriate for those with primary testicular failure, certain liver or eye conditions, or men who could be misusing it without monitoring.