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Flavonoid (the main active in chamomile) that binds benzodiazepine sites on GABA-A receptors, producing mild anxiolytic/sedative effects.
Evidence is thin and largely indirect; almost all human data come from whole chamomile extract, not isolated apigenin, and results are inconsistent. A randomized placebo-controlled pilot in chronic insomnia (34 adults, 270 mg chamomile twice daily for 28 days) found no significant differences from placebo on objective sleep-diary measures. Some trials in anxious or elderly populations report subjective benefit. There are no robust RCTs of isolated apigenin for sleep, so claims should be considered weak.
Human chamomile trials used ~200-560 mg extract/day; isolated apigenin sleep doses (~50 mg) are popular online but not validated by clinical trials.
Educational summary of doses studied — not a recommendation. Talk to a clinician before starting any supplement.
Educational summary of published research, checked against primary sources and linked inline. Not medical advice; supplements are not FDA-evaluated to treat disease. See our editorial policy.