Hims Testosterone SupportvsNugenix Total-T

The active ingredient is enclomiphene, a selective estrogen receptor modulator (SERM). It blocks estrogen receptors in the hypothalamus and pituitary, which the brain interprets as "estrogen is low." In response, the pituitary releases more luteinizing hormone (LH) and follicle-stimulating hormone (FSH), signaling the testicles to produce more of their own testosterone and to keep making sperm. This is fundamentally different from traditional testosterone replacement therapy (TRT), which adds testosterone from outside the body and can shut down the body's own production and reduce sperm counts. Hims sometimes bundles enclomiphene with supporting nutrients (such as zinc and B-vitamins) and, for eligible men, tadalafil for erectile function, but enclomiphene is the workhorse of the formula.

Total-T is a daily capsule blend that aims to nudge your body's own testosterone rather than supply any hormone. Boron (10 mg) may raise free, usable testosterone mainly by lowering sex-hormone-binding-globulin (SHBG), the protein that binds testosterone and keeps it inactive; a small 2011 study found 10 mg/day for one week lowered SHBG and estradiol and raised free testosterone, though it was tiny (8 men) and needs larger replication. Tesnor (a branded pomegranate-peel and cocoa-seed extract, 400 mg) has small manufacturer-linked trials suggesting modest free-testosterone or strength changes. The formula also includes Eurycoma longifolia (100 mg), L-citrulline malate (1,125 mg, which targets nitric oxide and blood flow), plus zinc, vitamin B6, and B12, which support normal hormone and energy metabolism. It contains no testosterone, steroids, or other hormones. Note Total-T does not contain fenugreek; that is the basis of the separate original Nugenix Free Testosterone product.

Enclomiphene has a credible clinical track record for secondary hypogonadism. In a 2014 randomized Phase II trial published in Fertility and Sterility (124 men with morning testosterone below 250 ng/dL), enclomiphene at 12.5 mg and 25 mg raised morning testosterone, LH, and FSH to levels comparable with 1% topical testosterone gel, while conserving sperm counts. A 2025 systematic review and meta-analysis of 10 randomized trials (819 men) found SERM therapy increased total testosterone by a mean of about 274 ng/dL versus placebo (95% CI ~192-356 ng/dL), with LH up ~4.7 IU/L and FSH up ~4.6 IU/L, and no significant difference in testosterone versus testosterone gel. Crucially, unlike testosterone gel (which in Phase III data reduced sperm density by roughly 33-57%), enclomiphene caused only minimal change in sperm density (about 12-15%), preserving fertility. Important caveat: despite this data, enclomiphene's new-drug application (Androxal) received an FDA Complete Response Letter in December 2015 requesting additional Phase 3 work, and development was discontinued for all indications in 2021, so it is not an FDA-approved drug.

Evidence is mixed and modest, and it rests on individual ingredients rather than the finished product. Boron at 10 mg has small short-term data suggesting it can raise free testosterone by lowering SHBG, but the key study was tiny (8 men, 7 days). The branded Tesnor extract (400 mg) has small, manufacturer-linked trials reporting free-testosterone and grip-strength changes. A 2023 systematic review in the International Journal of Impotence Research examined 27 proposed boosters (including Eurycoma longifolia, an ingredient in Total-T) and found inconsistent, mostly weak evidence that they raise serum total testosterone. A 2020 World Journal of Men's Health analysis of 50 'T-boosters' found 90% claimed to raise testosterone but only about 24.8% had supporting data, and roughly 10% contained ingredients shown to lower it. For context on related plant extracts, a 2024 PLOS One RCT of fenugreek (an ingredient not in Total-T) found a significant free-testosterone-index rise only at 1,800 mg and a saliva-testosterone increase versus placebo, while plasma total testosterone did not rise significantly versus placebo. No independent trial proves Total-T's specific full formula raises testosterone.

Commonly reported side effects of enclomiphene include headache, hot flashes, mood changes, nausea, and breast tenderness or sensitivity. Because it works partly by raising estradiol as well as testosterone, some men notice estrogen-related effects. If tadalafil is added, expect possible headache, flushing, indigestion, back or muscle pain, and nasal congestion. Less common but more serious concerns reported with SERMs in this class include visual disturbances (blurring or floaters) and blood-clot risk; vision changes warrant stopping the drug and contacting a clinician. Long-term safety data specific to enclomiphene is limited, and the 2025 meta-analysis explicitly noted its safety endpoints were underpowered, so ongoing monitoring matters. Seek urgent care for chest pain, a sudden vision change, signs of a clot (leg swelling or pain, shortness of breath), or an erection lasting over four hours.

Most users tolerate it well; the most common complaints are mild gastrointestinal upset, nausea, or a 'stomach burn,' especially early on or when taken on an empty stomach. Because the 10 mg boron is half the 20 mg adult tolerable upper intake level, stacking it with high-boron foods or other supplements could push intake higher and contribute to nausea or headache, with kidney strain reported only at far higher intakes. Theoretical hormone shifts mean men with prostate or other hormone-sensitive conditions should be cautious. Stop and seek care if you notice rash, swelling, trouble breathing, chest symptoms, or other signs of an allergic reaction. Dietary supplements are not reviewed by the FDA for safety or efficacy before they are sold.

As of 2026, Hims prices its testosterone program by plan length, paid upfront: roughly $199/month on a 3-month plan, about $139/month on a 5-month plan, and around $99/month on a 10-month plan, which bundles medication, provider check-ins, lab monitoring, and shipping. You typically prepay for the full 3-, 5-, or 10-month term, and these prescription-program charges are generally not refundable. Because enclomiphene is compounded and not FDA-approved, it is essentially never covered by insurance, so expect to pay out of pocket; some men find generic clomiphene or, where appropriate, FDA-approved TRT cheaper through a local prescriber and pharmacy. Lab fees and any office visits outside the bundle can add to the total, and prices change frequently, so confirm current figures directly with Hims.

As of 2026, expect roughly $60-$70 for a 30-day (90-capsule) bottle at full price from GNC, Amazon, or Nugenix.com (GNC commonly lists it around $69.99), working out to about $2.00-$2.50 per day. Nugenix heavily promotes a 'free trial' or 'complimentary bottle' (you pay shipping) that auto-enrolls you into recurring monthly billing of about $69.99 plus shipping; this practice has drawn hundreds of consumer complaints, so read the autoship terms and cancel before the trial ends if you do not want it. Multi-bottle bundles and subscriptions lower the per-bottle cost. Insurance and HSA/FSA generally do not cover dietary supplements.

This is aimed at adult men with lab-confirmed low testosterone of the secondary (hypogonadotropic) type, meaning the testicles can still work but the brain's hormonal signaling is low or inappropriately normal. It is especially relevant for younger men who want to raise testosterone while preserving fertility, since it does not suppress sperm production the way injected or topical testosterone does. It requires a baseline testosterone test, a licensed provider's review, and a prescription. It is not appropriate for men with primary (testicular failure) hypogonadism, those who only want a "boost" with normal labs, men trying to conceive without medical guidance, or anyone with a hormone-sensitive cancer or significant cardiovascular, liver, or vision conditions. Women, and anyone who is or may become pregnant, must not take it. Always disclose your full history to the prescriber.

Aimed at adult men (often marketed to those 40+) with normal-but-declining testosterone who want general support for energy, libido, strength, or workout performance. It is not for women, anyone under 18, or men seeking treatment for diagnosed hypogonadism. Avoid or consult a doctor first if you have kidney disease, hormone-sensitive cancer (e.g., prostate), or if you take blood-pressure, blood-thinner, or diabetes medication, or are on prescription testosterone. The 10 mg boron is half the 20 mg adult daily tolerable upper intake level, so account for boron from diet and any other supplements.