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HealthVetted
Longevity · Ingredient

Coenzyme Q10 (CoQ10)

BModerate evidenceHow we grade evidence
Research snapshot2sources cited2015–2018evidence window

What it is

Mitochondrial electron-transport cofactor and lipophilic antioxidant; declines with age.

What the evidence says

CoQ10 has the only longevity-relevant mortality data here, though confounded by co-supplementation. In the Swedish KiSel-10 RCT, 200 mg/day CoQ10 plus 200 ug selenium for 4 years in healthy elderly reduced cardiovascular mortality, with benefits persisting at 10- and 12-year follow-up (12-yr HR ~0.59). Because selenium was co-administered, CoQ10's independent contribution is uncertain, and the cohort was selenium-low. CoQ10 also has established benefit in heart failure but is not proven to extend lifespan.

Typical dose in trials

100-200 mg/day (often paired with selenium in the trial); ubiquinol better absorbed

Educational summary of doses studied — not a recommendation. Talk to a clinician before starting any supplement.

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Sources (2)

  1. Reduced Cardiovascular Mortality 10 Years after Supplementation with Selenium and Coenzyme Q10 for Four Years (KiSel-10) — PLOS ONE (PMID: 26624886) (2015)
  2. Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years — PLOS ONE (2018)
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Educational summary of published research, checked against primary sources and linked inline. Not medical advice; supplements are not FDA-evaluated to treat disease. See our editorial policy.