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Mitochondrial electron-transport cofactor and lipophilic antioxidant; declines with age.
CoQ10 has the only longevity-relevant mortality data here, though confounded by co-supplementation. In the Swedish KiSel-10 RCT, 200 mg/day CoQ10 plus 200 ug selenium for 4 years in healthy elderly reduced cardiovascular mortality, with benefits persisting at 10- and 12-year follow-up (12-yr HR ~0.59). Because selenium was co-administered, CoQ10's independent contribution is uncertain, and the cohort was selenium-low. CoQ10 also has established benefit in heart failure but is not proven to extend lifespan.
100-200 mg/day (often paired with selenium in the trial); ubiquinol better absorbed
Educational summary of doses studied — not a recommendation. Talk to a clinician before starting any supplement.
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