Fisetin
What it is
Plant flavonoid investigated as a senolytic to clear senescent ('zombie') cells.
What the evidence says
Fisetin's senolytic longevity claims rest almost entirely on mouse data, where it cleared senescent cells and extended lifespan. Human evidence is very limited: trials such as AFFIRM-LITE (intermittent 20 mg/kg/day) and osteoarthritis/COVID studies are small, mostly pilot-stage, and results are only beginning to report. As of now there are no robust published RCTs demonstrating that fisetin extends healthspan or improves aging outcomes in humans. Treat longevity claims as unproven.
Mouse-derived intermittent dosing (~20 mg/kg/day for 2-3 days) used in trials; no established human regimen
Educational summary of doses studied — not a recommendation. Talk to a clinician before starting any supplement.
Sources (1)
- Fisetin is a senotherapeutic that extends health and lifespan (preclinical basis; human AFFIRM trials ongoing) — EBioMedicine (PMID: 30279143) (2018)
Educational summary of published research, checked against primary sources and linked inline. Not medical advice; supplements are not FDA-evaluated to treat disease. See our editorial policy.