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Polyphenol and putative sirtuin (SIRT1) activator; popularized by the 'red wine' longevity hypothesis.
Despite its longevity reputation, human evidence is mixed and there is no lifespan or healthspan-extension data in people. A meta-analysis of 11 RCTs found resveratrol improved glucose control and insulin sensitivity in people with diabetes but had no effect on glycemic measures in non-diabetic individuals. Other meta-analyses report small cardiometabolic improvements, but findings are inconsistent across endpoints. Bioavailability is poor, and benefits, where present, are modest and condition-specific rather than anti-aging.
Highly variable in trials (~150 mg up to 1000-1500 mg/day); no consensus longevity dose
Educational summary of doses studied — not a recommendation. Talk to a clinician before starting any supplement.
Educational summary of published research, checked against primary sources and linked inline. Not medical advice; supplements are not FDA-evaluated to treat disease. See our editorial policy.