Resveratrol
What it is
Polyphenol and putative sirtuin (SIRT1) activator; popularized by the 'red wine' longevity hypothesis.
What the evidence says
Despite its longevity reputation, human evidence is mixed and there is no lifespan or healthspan-extension data in people. A meta-analysis of 11 RCTs found resveratrol improved glucose control and insulin sensitivity in people with diabetes but had no effect on glycemic measures in non-diabetic individuals. Other meta-analyses report small cardiometabolic improvements, but findings are inconsistent across endpoints. Bioavailability is poor, and benefits, where present, are modest and condition-specific rather than anti-aging.
Highly variable in trials (~150 mg up to 1000-1500 mg/day); no consensus longevity dose
Educational summary of doses studied — not a recommendation. Talk to a clinician before starting any supplement.
Sources (1)
- Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials — American Journal of Clinical Nutrition (PMID: 24695890) (2014)
Educational summary of published research, checked against primary sources and linked inline. Not medical advice; supplements are not FDA-evaluated to treat disease. See our editorial policy.