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NAD+ precursor intended to restore age-related decline in cellular NAD+.
Human RCTs consistently confirm NR is safe and raises blood NAD+ (often 40-90%, up to ~2.6-3x at high doses). The problem is downstream benefit: trials repeatedly fail to translate NAD+ elevation into clinical gains. A 24-week long-COVID RCT at 2000 mg/day tripled NAD+ but did not improve cognition, fatigue, sleep, or mood versus placebo, and a meta-analysis found minimal benefit for muscle in older adults. Evidence for actual longevity or function endpoints is weak.
250-1000 mg/day (up to 2000 mg/day studied); reliably raises NAD+
Educational summary of doses studied — not a recommendation. Talk to a clinician before starting any supplement.
Educational summary of published research, checked against primary sources and linked inline. Not medical advice; supplements are not FDA-evaluated to treat disease. See our editorial policy.